Hydroxychloroquine Sulfate EP Impurity D DiHBr (Desethyl Chloroquine DiHBr) CAS 1476-52-4(free base)
| CAS No. | 1476-52-4(free base) |
| Molecular Formula | C16H22ClN3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Hydroxychloroquine Sulfate EP Impurity D DiHBr (Desethyl Chloroquine DiHBr) (CAS 1476-52-4(free base)) is a certified pharmaceutical impurity reference standard with the molecular formula C16H22ClN3HBr and a molecular weight of 372.74 g/mol.
Structurally, Hydroxychloroquine Sulfate EP Impurity D DiHBr (Desethyl Chloroquine DiHBr) (C16H22ClN3HBr) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine/bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 372.74 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Hydroxychloroquine Sulfate EP Impurity D DiHBr (Desethyl Chloroquine DiHBr) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H22ClN3 2*HBr |
| Molecular Weight | 372.74 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 3 |
Related Hydroxychloroquine Standards
- Hydroxychloroquine Impurity 75 (CAS 100713-49-3)
- Hydroxychloroquine EP Impurity B (CAS 103152-84-7)
- Hydroxychloroquine EP Impurity B Hydrogen sulfate (CAS 103152-84-7(free base))
- Hydroxychloroquine EP Impurity E (CAS 10500-64-8)
- Hydroxychloroquine Impurity 32 (CAS 106007-99-2)
- Hydroxychloroquine Impurity 30 (CAS 1077-74-3)
- Hydroxychloroquine Impurity 53 (CAS 109-83-1)
- Hydroxychloroquine D5 (CAS 118-42-3(Unlabelled))
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- Methyl (2S,4S)-4-(3-methyl-4-nitrophenoxy)-2-pyrrolidinecarboxylate (CAS 1217646-95-1)
- Des-Ala21-Tirzepatide (CAS CATO-CPTD788952)
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